Κάνναβη και Επιληψία

ΚΑΝΝΑΒΗ ΚΑΙ ΕΠΙΛΗΨΙΑ

Κάνναβη και Επιληψία.

Οι σύγχρονες µελέτες σε ευρωπαϊκό και διεθνές επίπεδο αποδέχονται τις θεραπευτικές ιδιότητες της κάνναβης. Σε αυτό το πλαίσιο, διακρίνεται σαφώς η τάση θεσµοθέτησης της πρόσβασης των ασθενών σε προϊόντα φαρµακευτικής κάνναβης και ο διάλογος για τη ρύθµιση του πεδίου της παραγωγής των τελικών προϊόντων, του ελέγχου και της αδειοδότησής τους, της διάθεσης τους και της ιατρικής χρήσης παραµένει ανοιχτός και υπό εξέλιξη εντός της επιστηµονικής κοινότητας, δεδοµένου των ιδιαιτεροτήτων τόσο της διαδικασίας παραγωγής, όσο και των τελικών προϊόντων, καθώς και των ανοιχτών προοπτικών της ιατρικής χρήσης. H πρώτη πρόταση της αιτιολογικής έκθεσης, για το σχέδιο νόμου: Διατάξεις για την παραγωγή τελικών προϊόντων φαρμακευτικής κάνναβης. Access date 24.5.2018

Θα προσπαθήσουμε να δούμε τί υπάρχει στην ιατρική βιβλιογραφία σχετικά με τη χρήση της κάνναβης για τη θεραπεία ή έστω τη ανακούφιση νευρολογικών παθήσεων και αυτό το άρθρο είναι μέρος αυτής της προσπάθειας. Γίνεται μια ανασκόπηση της βιβλιογραφίας για τη χρήση της κάνναβης στην επιληψία αφού βέβαια πρώτα περιγράψουμε εν συντομία τις πλευρές της νόσου που μας ενδιαφέρουν.

Επιληψίαείναι ένα συνηθισμένο νόσημα κατά το οποίο διαταρασσεται η ηλεκτρική δραστηριότητα του εγκεφάλου με αποτέλεσμα να προκαλούνται διάφορα συμπτώματα όπως τινάγματα, μουδιάσματα, σπασμους, πτώσεις, απώλεια της συνείδησης (που ο κόσμος τη λέει λανθασμένα “λιποθυμία”) κλπ. Υπάρχουν πολλοί τρόποι για να διακρίνει κανείς τις τα είδη της επιληψίας (επιληπτικών κρίσεων). Ο τρόπος που θα χρησιμοποιήσουμε εμείς σ’ αυτό το άρθρο είναι το είδος της αιτίας: στην ιδιοπαθή επιληψία (αν η αιτία είναι άγνωστη) και στην δευτεροπαθή επιληψία (αν η αιτία είναι κάποια βλάβη του εγκεφάλου από όγκο, αιμάτωμα κλπ).

Η κάνναβη ή χασίς ή μαριχουάνα, οπως είναι γνωστό το φυτό με το επιστημονικό όνομα Cannabis Sativa L, περιέχει μεταξύ άλλων ουσίες που είναι γνωστές ώς κανναβινοειδή. Τα βασικότερα κανναβινοειδή είναι

  • η τετραϋδροκανναβινόλη (THC) που είναι υπεύθυνη για την “ευφορική / ψυχαγωγική” δράση (κοινώς “μαστούρωμα”) που προκαλεί η κάνναβη
  • και η κανναβιδιόλη (CBD) η οποία δεν έχει καμμία ψυχοτρόπο δράση αλλά θεωρείται ότι μπορεί ενδεχομένως να έχει κάποια θετική δράση σε ορισμένα είδη ιδιοπαθούς επιληψίας. Ποιά είναι αυτά τα είδη;
    1. Το σύνδρομο Lennox-Gastaut (LGS). Είναι ένα επιληπτικό συνδρομο της παιδική ηλικίας που συνοδεύεται με νοητική καθυστέρηση και αντιμετωπίζεται πολύ δυσκολα με τα υπάρχοντα φάρμακα. Αντιστοιχεί στο 2-5% της παιδικής επιληψίας.1
    2. Το σύνδρομο Dravet. Είναι ένα από τα πολύ βαριά επιληπτικά συνδρομα που θεωρείται ανίατο. Η συχνότητά του είναι λιγότερο από 1 στα 10.000 παιδιά. Συνοδεύεται με βαρειά νοητική καθυστέρηση και διαταραχές συμπεριφοράς.2
Κάνναβη και επιληψία - Συμπεράσματα
  • Γιά τις έρευνες χρησιμοποιήθηκε ένα καθαρό προϊον της κάνναβης χωρίς ψυχοτρόπο δράση και όχι η ίδια η κάνναβη ολόκληρη.
  • Φάνηκε ότι μπορεί η κανναβιδιόλη (CBD) να μειώσει ίσως τις κρίσεις σε δύο μόνο είδη παιδικής επιληψίας.
  • Τα είδη αυτά της επιληψίας είναι τύποι παιδικής επιληψίας τα οποία είναι πολύ σπάνια και με πολύ βαρειά κλινική εικόνα.
  • Σε καμμία εργασία σε επιληψία ενηλίκων δεν φαίνεται κάποια επιδραση της κάνναβης.

Παραπομπές

1. Eplepsy foundation (LGS). Access date 24.5.2018
2. Dravet Syndrome foundation. Access date 24.5.2018

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