Aubagio

Aubagio (Τεριφλουνομίδη)

bbk-AubaMOAΟι μηχανισμοί της Πολλαπλής Σκλήρυνσης, δεν μας είναι ακόμη όλοι γνωστοί. Ενας από τους μηχανισμούς που γνωρίζουμε είναι ο εξής: Κάποια κύτταρα του αίματος, τα Τ και Β λεμφοκύτταρα, αυτοενεργοποιούνται, πολλαπλασιάζονται ραγδαία και εισέρχονται σε μεγάλες ποσότητες μέσα στο Κεντρικό Νευρικό Σύστημα (εγκέφαλο και νωτιαίο μυελό), περνώντας μέσα από τον αιματο-εγκεφαλικό φραγμό (βλ. διπλανή εικόνα). Τα κύτταρα αυτά στη συνέχεια “επιτίθενται” και προκαλούν καταστροφές  στα νευρικά κύτταρα.

Πιστεύεται ότι το Aubagio αναστέλλει, δηλαδή σταματά, την υπερπαραγωγή αυτών των κυττάρων και με τον τρόπο αυτό περιορίζονται ή και αποτρέπονται οι βλάβες που προκαλούν οι ώσεις της Πολλαπλής Σκλήρυνσης. Είναι δηλαδή το Aubagio ένα ανοσο-τροποποιητικό φάρμακο (τροποποιεί την αυτο-άνοση αντίδραση του οργανισμού). O τρόπος δράσης πάντως του φαρμάκου δεν είναι ακόμη απολύτως γνωστός.*

Σε μελέτες που έγιναν προκειμένου να δοθεί η άδεια κυκλοφορίας του φαρμάκου φαίνεται ότι μπορεί να προκαλέσει σημαντική μείωση των ώσεων της Πολλαπλής Σκλήρυνσης και των βλαβών που προκαλεί η κάθε ώση. 
AubagioTbl

Το Aubagio κυκλοφορεί σε χάπια των 7 ή των 14mg που λαμβάνονται μία φορά την ημέρα κάθε μέρα ανεξάρτητα από τη λήψη τροφής. Αποτελεί σήμερα ένα ακόμη όπλο στη μάχη μας κατά της Πολλαπλής Σκλήρυνσης.

Η επιλογή του πρέπει να γίνεται μετά από πρόταση του θεράποντα ιατρού ο οποίος θα το επιλέξει μετά από συζήτηση και ενημέρωση του ασθενούς και αφού πάρει υπόψη του τις ιδιαίτερες ανάγκες και προτιμήσεις του αλλά και τη μορφή και τη φάση της νόσου.

Ένα από ιδιαίτερο χαρακτηριστικό του φαρμάκου είναι ότι για να απομακρυνθεί πλήρως από τον οργανισμό μετά την τελευταία δόση, χρειάζεται να περάσουν μέχρι και δύο χρόνια.

 

Ποιές εξετάσεις πρέπει να γίνουν πριν την έναρξη θεραπείας με Aubagio

  1. Ελεγχος της ηπατικής λειτουργίας με την μέτρηση των τρανσαμινασών
  2. Γενική αίματος
  3. Ελεγχος για φυματίωση
  4. Ελεγχος για υπέρταση

 

Τί πρέπει να προσέχουν αυτοί που κάνουν θεραπεία με Aubagio

  • Αν παθαίνουν συχνές λοιμώξεις (ίσως αυτό να σημαίνει σοβαρή μείωση των λευκών τους αιμοσφαιρίων)
  • Εμφάνιση αλλεργικής αντίδρασης
  • Μουδιάσματα στα χέρια ή στα πόδια που είναι διαφορετικά από αυτά της Πολλαπλής Σκλήρυνσης
  • Αναπνευστικά προβλήματα
  • Υπέρταση
  • Εμβόλια

Αν οτιδήποτε από τα παραπάνω συμβαίνει θα πρέπει να ενημερώσουν άμεσα το γιατρό τους.

ΔΕΝ συνιστάται η χρήση του Aubagio σε:
  • Περιόδους γαλουχίας ή εγκυμοσύνης.
  • Σε βαριά ηπατική ανεπάρκεια.
  • Σε βαριά νεφρική ανεπάρκεια.

 

Να θυμάστε πάντα: Μήν παίρνετε ή μή διακόπτετε ποτέ κάποιο φάρμακο, χωρίς την οδηγία του γιατρού σας.Χαράλαμπος Καραγιαννίδης, Νευρολόγος-Ψυχίατρος
 

Άλλα φάρμακα για την πολλαπλή σκλήρυνση

 

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